Molecular Formula | C64H116N22O19 |
Molar Mass | 1497.74 |
Solubility | H2O: soluble |
Appearance | lyophilized powder |
Color | white |
Storage Condition | -20°C |
In vitro study | It is found that Autocamtide-2-related inhibitory peptide (a novel synthetic peptide ATP) is a potent inhibitor of CaM-kinase II with an IC 50 of 40 nM, which is active in the presence or absence of Ca 2+ /calmodulin. It is 50 and 500 times more potent than CaMK-(281-302Ala286) and KN-93,respectively, under the assay condition used. |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36 - Irritating to the eyes R11 - Highly Flammable |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
WGK Germany | 3 |
biological activity | Autocamtide-2-related inhibition peptide is a highly specific, potent inhibitor of CaMKII with an IC50 value of 40 nM. |
Target | IC50: 40 nM (CaMKII). |
in vitro study | It is found that Autocamtide-2-related "is a pot inhibitor of CaM-kinase II with an IC 50 of 40 nM, which is active in the presence or absence of Ca 2 /calmodulin. It is 50 and 500 times more potent than CaMK-(281-302Ala286) and KN-93,respectively, under the assay condition used. |